Drugs & Vitamins

Imipramine Injection Active Ingredients: Imipramine Injection What is imipramine injection? What should I tell my health care provider before I take this medicine? How should I use this medicine? What if I miss a dose? What drug(s) may interact with imipramine? What side effects may I notice from receiving imipramine? What should I watch for while taking imipramine? Where can I keep my medicine? What is imipramine injection? (Back to top) IMIPRAMINE (Tofranil®) is an antidepressant. Imipramine can help to lift your spirits by treating your depression. Generic imipramine injections are not yet available. What should I tell my health care provider before I take this medicine? (Back to top) They need to know if you have any of these conditions: •an alcohol problem •asthma, difficulty breathing •blood disorders or disease •diabetes •difficulty passing urine, prostate trouble •glaucoma •having intramuscular injections •heart disease, or recent heart attack •liver disease •over active thyroid •Parkinson's disease •schizophrenia •seizures (convulsions) •stomach disease •an unusual or allergic reaction to imipramine, sulfites, other medicines, foods, dyes, or preservatives •pregnant or trying to get pregnant •breast-feeding How should I use this medicine? (Back to top) Imipramine is for injection into a muscle. It is given by a health-care professional. Contact your pediatrician or health care professional regarding the use of this medicine in children. Special care may be needed. Elderly patients over 65 years old and adolescents may have a stronger reaction to this medicine and need smaller doses. What if I miss a dose? (Back to top) This does not apply. What drug(s) may interact with imipramine? (Back to top) Imipramine can interact with many other medicines. Some interactions can be very important. Make sure your prescriber or health care professional knows about all other medicines you are taking. Many important interactions are listed below: Do not take Imipramine with any of the following medications: •astemizole (Hismanal®) •cisapride (Propulsid®) •probucol •terfenadine (Seldane®) •thioridazine (Mellaril®) •medicines called MAO inhibitors-phenelzine (Nardil®), tranylcypromine (Parnate®), isocarboxazid (Marplan®), selegiline (Eldepryl®) •other medicines for mental depression (may be duplicate therapies or cause additive side effects) Imipramine may also interact with any of the following medications: •alcohol •antacids •atropine and related drugs like hyoscyamine, scopolamine, tolterodine and others •barbiturate medicines for inducing sleep or treating seizures (convulsions), such as phenobarbital •blood thinners, such as warfarin •bromocriptine •bupropion •cimetidine •clonidine •cocaine •delavirdine •diphenoxylate •disulfiram •donepezil •drugs for treating HIV infection •female hormones, including contraceptive or birth control pills and estrogen •galantamine •herbs and dietary supplements like ephedra (Ma huang), kava kava, SAM-e, St. John's wort, valerian, or others •imatinib, STI-571 •kaolin; pectin •labetalol •levodopa and other medicines for movement problems like Parkinson's disease •lithium •medicines for anxiety or sleeping problems •medicines for colds, flu and breathing difficulties, like pseudoephedrine •medicines for hay fever or allergies (antihistamines) •medicines for weight loss or appetite control •medicines used to regulate abnormal heartbeat or to treat other heart conditions (examples: amiodarone, bepridil, disopyramide, dofetilide, encainide, flecainide, ibutilide, mibefradil, procainamide, propafenone, quinidine, and others) •metoclopramide •muscle relaxants, like cyclobenzaprine •other medicines for mental or mood problems and psychotic disturbances •prescription pain medications like morphine, codeine, tramadol and others •procarbazine •seizure (convulsion) or epilepsy medicine such as carbamazepine or phenytoin •stimulants like dexmethylphenidate or methylphenidate •some antibiotics (examples: erythromycin, gatifloxacin, levofloxacin, linezolid, moxifloxacin, sotalol, sparfloxacin) •tacrine •thyroid hormones such as levothyroxine Tell your prescriber or health care professional about all other medicines you are taking, including non-prescription medicines, nutritional supplements, or herbal products. Also tell your prescriber or health care professional if you are a frequent user of drinks with caffeine or alcohol, if you smoke, or if you use illegal drugs. These may affect the way your medicine works. Check with your health care professional before stopping or starting any of your medicines. What side effects may I notice from receiving imipramine? (Back to top) Side effects that you should report to your prescriber or health care professional as soon as possible: •abnormal production of milk in females •blurred vision or eye pain •breast enlargement in both males and females •confusion, hallucinations (seeing or hearing things that are not really there) •difficulty breathing •fainting spells •fever •irregular or fast, pounding heartbeat, palpitations •muscle stiffness, or spasms •pain or difficulty passing urine, loss of bladder control •seizures (convulsions) •sexual difficulties (decreased sexual ability or desire, difficulty ejaculating) •stomach pain •swelling of the testicles •tingling, pain, or numbness in the feet or hands •tremor (shaking) •unusual weakness or tiredness •yellowing of the eyes or skin Side effects that usually do not require medical attention (report to your prescriber or health care professional if they continue or are bothersome): •anxiety •constipation, or diarrhea •drowsiness or dizziness •dry mouth •headache •increased sensitivity of the skin to sun or ultraviolet light •loss of appetite •nausea, vomiting •skin rash or itching •weight gain or loss What should I watch for while taking imipramine? (Back to top) Visit your prescriber or health care professional for regular checks on your progress. It can take several days or weeks before you feel the full effect of imipramine. If you have been receiving imipramine regularly for some time, you must gradually reduce the dose or you may get severe side effects. Your prescriber or health care professional will advise you. Even after you stop receiving imipramine it can still affect your body for several days. You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how imipramine affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol can increase dizziness and drowsiness. Avoid alcoholic drinks. Do not treat yourself for coughs, colds or allergies without asking your prescriber or health care professional for advice. Some ingredients can increase possible side effects. Your mouth may get dry. Chewing sugarless gum or sucking hard candy, and drinking plenty of water will help. Imipramine may cause dry eyes and blurred vision. If you wear contact lenses you may feel some discomfort. Lubricating drops may help. See your ophthalmologist if the problem does not go away or is severe. Imipramine may make your skin more sensitive to the sun. Keep out of the sun, or wear protective clothing outdoors and use a sunscreen. Do not use sun lamps or sun tanning beds or booths. Imipramine can affect blood glucose (sugar) levels. If you are a diabetic, check your blood sugar more often than usual, especially during the first few weeks of imipramine treatment. Call your prescriber or health care professional for advice if you notice a change in the results of blood or urine glucose tests. If you are going to have surgery or will need an x-ray procedure that uses contrast agents, tell your prescriber or health care professional that you are taking this medicine. Where can I keep my medicine? (Back to top) Keep out of the reach of children. Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). On storage minute crystals may form in ampuls. These will redissolve with no adverse effects if the ampul is held under hot tap water for one minute. Throw away any unused medicine after the expiration date. Last Updated:04/19/2002 CLINICAL PHARMACOLOGY© GOLD STANDARD MULTIMEDIA INC, ALL RIGHTS RESERVED

Note: The above information is intended to supplement, not substitute for, the expertise and judgment of your physician, pharmacist, or other healthcare professional. It should not be construed to indicate that the use of the product is safe, appropriate, or effective for you. Consult your healthcare professional before taking the product.